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The new plan was developed during a series of individual and joint DOE-NIH workshops on various aspects of the project. The DOE planning committee, chaired by Raymond Gesteland (University of Utah), met May 28-29 with its NIH counterpart and a broad group of 120 researchers for a final evaluation of the plan. At that meeting, the consensus was that (1) the U.S. HGP should stick with its original goal of achieving full and highly accurate human sequence and (2) improving sequencing capacity is paramount. Priorities for the next 5 years include the following: * Clone and sequence full-length cDNAs of humans and model organisms, especially mouse. * Develop and improve software for determining and assembling sequences and recognizing expressed genes. * Identify single-nucleotide polymorphisms as measures of human variation. * Continue to study ethical, legal, and social issues related to the project. Human Genome Project Value Although initially controversial in the scientific community, the genome projects value has been proved beyond question. The wider biological and scientific communities in the United States and around the world are developing tools and applications for the new data in such wide-ranging fields as medicine, agriculture, bioremediation, and industrial enzymology. International efforts have played a critical role in the projects success, with at least 18 countries now supporting programs for analyzing the genomes of a variety of organisms ranging from microbes to economically important plants and animals to humans. |
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